Randomized clinical trials

design, practice, and reporting by David Machin

Published by John Wiley & Sons in Chichester, West Sussex, Hoboken, NJ .
Written in

  • Clinical trials,
  • Clinical trials -- Statistical methods,
  • Biomedical Research -- methods,
  • Randomized Controlled Trials as Topic -- methods,
  • Data Interpretation, Statistical,
  • Research Design

  • Edition Notes

    Includes bibliographical references and index.

    StatementDavid Machin, Michael J. Campbell.
    ContributionsCampbell, Michael J., PhD.
    LC ClassificationsR853.C55 M337 2010
    The Physical Object
    Paginationp. ;
    ID Numbers
    Open LibraryOL24013872M
    ISBN 109780471498124
    LC Control Number2009054234


    Randomized Clinical Trials by David Machin is a comprehensive book that delves into the design, practice, and reporting of clinical trials. Published in 2010, this insightful resource is a must-have for researchers, clinicians, and students in the field of biomedical research.

    About the Author

    David Machin is a prominent expert in the field of clinical trials. With years of experience and numerous publications to his name, Machin brings a wealth of knowledge and expertise to this book. His expertise is evident throughout the pages, making it an authoritative resource for all those interested in the subject.

    Overview of the Book

    As the subtitle suggests, Randomized Clinical Trials covers various aspects of clinical trials, including design, practice, and reporting. The book explores topics such as the statistical methods employed in clinical trials, data interpretation, research design, and the significance of randomized controlled trials.

    The Importance of Clinical Trials

    Clinical trials play a crucial role in providing evidence-based medicine. They allow researchers to evaluate the effectiveness of interventions, treatments, and medications in a controlled environment. Randomized Clinical Trials by David Machin emphasizes the importance of robust study design and appropriate statistical analysis to ensure reliable and valid results.

    Designing and Conducting Clinical Trials

    This book equips readers with the knowledge and tools needed to design and conduct clinical trials effectively. It covers important topics such as randomization, blinding, sample size determination, and ethical considerations. Machin provides step-by-step guidance on the different phases of a clinical trial, from planning to implementation, enabling researchers to conduct high-quality studies.

    Statistical Methods in Clinical Trials

    A thorough understanding of statistical methods is essential for interpreting the results of clinical trials. Machin's book covers various statistical techniques used in clinical trials, such as hypothesis testing, confidence intervals, and survival analysis. By explaining these methods in a clear and accessible manner, readers can gain confidence in analyzing and interpreting clinical trial data.

    Reporting and Publication of Clinical Trials

    Proper reporting of clinical trials is crucial for transparency and reproducibility. The book emphasizes the importance of adhering to reporting guidelines, such as CONSORT, to ensure accurate and comprehensive reporting. Machin provides insights into the publication process and offers tips on writing clear and concise manuscripts that effectively communicate study findings.


    Randomized Clinical Trials by David Machin is an invaluable resource for anyone involved in clinical research. Its comprehensive coverage of study design, statistical methods, and reporting guidelines make it a valuable reference for researchers, clinicians, and students alike. Whether you are looking to download the book in PDF, ePub, mobi, or text format, or read it online for free, this book will undoubtedly enhance your understanding of randomized clinical trials.